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【摘要】 目的：对纳洛酮治疗慢性呼吸衰竭并肺性脑病的临床效果进行分析和观察。方法：以本院2009年1月-2012年1月收治的60例慢性呼吸衰竭并发肺性脑病患者为研究对象，采用随机分配的原则将所有患者分成对照组和试验组各30例。对照组患者采用常规的治疗措施，试验组患者则在常规治疗措施的基础上，增加纳洛酮进行治疗。对两组患者的血气分析、清醒时间以及临床效果进行观察和比较。结果：两组患者在血气分析上均有效改善。治疗后，两组患者的PaO2以及PaCO2均有明显变化，PaO2显著升高，PaCO2显著下降，两组治疗前后比较差异均有统计学意义（P<0.05）；试验组清醒时间明显短于对照组患者，两组比较差异有统计学意义（P<0.05）。试验组的总有效率明显高于对照组，两组比较差异有统计学意义（P<0.05）。结论：对慢性呼吸衰竭并发肺性脑病患者使用纳洛酮进行治疗，能够有效帮助患者恢复神志，有利于肺通气的改善，具有较高的临床应用价值，值得推广和普及。
【关键词】 纳洛酮； 慢性呼吸衰竭； 肺性脑病
The Clinical Observation of Naloxone in Treatment of Chronic Respiratory Failure and Pulmonary Encephalopathy/ZHONG Fu-chu.//Medical Innovation of China，2013，10（35）：006-007
【Abstract】 Objective：To analyze and observe the clinical effect of the naloxone in the treatment of chronic respiratory failure and pulmonary encephalopathy. Method： The clinical study mainly by the hospital from January 2009 to January 2012 were analyzed in 60 cases of chronic respiratory failure complicated by pulmonary encephalopathy patients as the research object， based on the principle of random distribution， patients were divided into the control group and the experimental group， each group of 30 cases. The control group was treated by routine treatment， the experimental group patients on the basis of routine treatment， increasing treated with naloxone. On two groups of patients with blood gas analysis， awaked time and clinical effect were observed and compared.Result： All patients of PaO2 and PaCO2 were changed significantly. PaO2 was significant increasing and PaCO2 was significant decreasing， and the difference of before and after treatment between the two groups were all statistically significant（P<0.05）. The awaked time of the experimental group was significantly shorter than the control group（P<0.05）and clinical effect rate of the experimental group was significantly better than the control group（P<0.05）.Conclusion： For patients with chronic respiratory failure complicated by pulmonary encephalopathy treated with naloxone， can effectively help patients recover consciousness， is beneficial to the improvement of pulmonary ventilation， is of high clinical application value， worthy of promotion and popularization.
【Key words】 Naloxone； Chronic respiratory failure； Pulmonary encephalopathy
First-author’s address：The Chest Hospital of Jiangxi Province，Nanchang 330006，China
doi：10.3969/j.issn.1674-4985.2013.35.003
在臨床上，肺性脑病主要是在慢性肺部疾病的基础上发展而来的，一般是由于患者出现重度低氧或者高碳酸血症时，导致中枢神经系统功能受到影响，从而引发的一种疾病[1]。作为一种常见的呼吸内科疾病，其本身的病情特点较为严重，对患者的生命造成了严重的威胁[2]。在临床治疗方法上，纳洛酮是一种常见的治疗药物，作为一种特异性阿片受体拮抗剂，其能够对β-内啡肽的毒性进行阻断，从而使中枢呼吸恢复正常，对缺氧以及二氧化碳滞留具有十分显著的治疗效果，有利于患者脑缺血以及脑水肿的改善，进一步帮助患者恢复脑功能健康[3]。此次临床研究中，本院对收治的60例慢性呼吸衰竭并肺性脑病患者进行分组治疗，试验组采用纳洛酮进行治疗，效果显著，现报告如下。
【关键词】 纳洛酮； 慢性呼吸衰竭； 肺性脑病
The Clinical Observation of Naloxone in Treatment of Chronic Respiratory Failure and Pulmonary Encephalopathy/ZHONG Fu-chu.//Medical Innovation of China，2013，10（35）：006-007
【Abstract】 Objective：To analyze and observe the clinical effect of the naloxone in the treatment of chronic respiratory failure and pulmonary encephalopathy. Method： The clinical study mainly by the hospital from January 2009 to January 2012 were analyzed in 60 cases of chronic respiratory failure complicated by pulmonary encephalopathy patients as the research object， based on the principle of random distribution， patients were divided into the control group and the experimental group， each group of 30 cases. The control group was treated by routine treatment， the experimental group patients on the basis of routine treatment， increasing treated with naloxone. On two groups of patients with blood gas analysis， awaked time and clinical effect were observed and compared.Result： All patients of PaO2 and PaCO2 were changed significantly. PaO2 was significant increasing and PaCO2 was significant decreasing， and the difference of before and after treatment between the two groups were all statistically significant（P<0.05）. The awaked time of the experimental group was significantly shorter than the control group（P<0.05）and clinical effect rate of the experimental group was significantly better than the control group（P<0.05）.Conclusion： For patients with chronic respiratory failure complicated by pulmonary encephalopathy treated with naloxone， can effectively help patients recover consciousness， is beneficial to the improvement of pulmonary ventilation， is of high clinical application value， worthy of promotion and popularization.
【Key words】 Naloxone； Chronic respiratory failure； Pulmonary encephalopathy
First-author’s address：The Chest Hospital of Jiangxi Province，Nanchang 330006，China
doi：10.3969/j.issn.1674-4985.2013.35.003
在臨床上，肺性脑病主要是在慢性肺部疾病的基础上发展而来的，一般是由于患者出现重度低氧或者高碳酸血症时，导致中枢神经系统功能受到影响，从而引发的一种疾病[1]。作为一种常见的呼吸内科疾病，其本身的病情特点较为严重，对患者的生命造成了严重的威胁[2]。在临床治疗方法上，纳洛酮是一种常见的治疗药物，作为一种特异性阿片受体拮抗剂，其能够对β-内啡肽的毒性进行阻断，从而使中枢呼吸恢复正常，对缺氧以及二氧化碳滞留具有十分显著的治疗效果，有利于患者脑缺血以及脑水肿的改善，进一步帮助患者恢复脑功能健康[3]。此次临床研究中，本院对收治的60例慢性呼吸衰竭并肺性脑病患者进行分组治疗，试验组采用纳洛酮进行治疗，效果显著，现报告如下。