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本文介绍用地高辛抗体治疗洋地黄中毒。抗体制备:将与牛血清白蛋白结合的地高辛和福氏完全佐剂免疫家兔,6～30周后采血得地高辛抗体,效价为稀释750倍的原血清1ml 可结合 H~3—地高辛43.5μg 的50％。疗效:实验狗25只分3组。对照组12只狗,给地高辛0.16mg/kg 后心电图出现各种异常节律,并持续30分钟以上未能自然转复。第1组8只狗,地高辛剂量同上,在心律不齐发生30分钟后给以地高辛抗体,全部复律,游离地高辛血浓度比对照组明显降低但总地高辛浓度无差异。第2组5只狗,给地高辛后30分钟即给以地高辛抗体,也全部复律,所需时间比第1组短,总地高辛浓度上升,游离地高辛浓度则急剧下降。心肌内各部位地高辛浓度,对照组,第1组及第2组有逐渐下降的倾向,特别是对照组与第2组间有
This article describes digoxin antibody treatment of digitalis poisoning. Antibody preparation: The rabbits were immunized with digoxin and Freund’s complete adjuvant conjugated with bovine serum albumin, digoxin antibody was obtained after 6 to 30 weeks, the titer was diluted 1: 750 with the original serum 1ml can be combined with H ~ 3- 50% of 43.5 μg of digoxin. Efficacy: Experimental dogs 25 points 3 groups. Twelve dogs in the control group developed various abnormal rhythms of electrocardiogram after 0.16 mg / kg of digoxin and did not spontaneously recover for more than 30 minutes. The first group of 8 dogs, digoxin dose ibid, 30 minutes after the occurrence of arrhythmia to digoxin antibody, all cardioversion, free digoxin blood concentration was significantly lower than the control group, but the total digoxin concentration difference. The second group of five dogs, given digoxin 30 minutes after giving anti-digoxin antibody, also all cardioversion, the time required shorter than group 1, the total digoxin concentration increased, the concentration of free digoxin sharp decline. The digoxin concentration in each part of the myocardium tended to decrease gradually in the control group, the first group and the second group, especially between the control group and the second group