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目的 探讨角膜移植术后病人外周血免疫功能的动态变化。方法 检测26例行带环形巩膜全角膜移植术(CST)和76例部分穿透性角膜移植术(PKP)病人的术前和术后不同时期体液与细胞免疫指标,并进行对比分析。结果 角膜移植病人的细胞和体液免疫术前与术后比较有显著差异(P<0.05),带环形巩膜全角膜移植术病人体液免疫持续时间较部分穿透性角膜移植术组延长,细胞免疫持续时间差异无显著性。结论 带环形巩膜全角膜移植术后体液免疫较部分穿透性角膜移植反应程度高,可能是排斥率高的原因之一。
Objective To investigate the dynamic changes of peripheral blood immune function after corneal transplantation in patients. Methods Twenty-six patients with ring scleral corneal allograft (CST) and 76 patients with partial penetrating keratoplasty (PKP) were enrolled in this study. The humoral and cellular immune indexes were measured before and after surgery and compared. Results The cell and humoral immunity of corneal transplant patients were significantly different before and after surgery (P <0.05). The duration of humoral immunity of patients with corneal allograft was longer than that of partially penetrating keratoplasty and the cellular immunity continued Time difference was not significant. Conclusion The humoral immunity after partial corneal transplantation with annular sclera is better than that of partial penetrating keratoplasty, which may be one of the reasons of high exclusion rate.