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典型的辐射诱发小鼠精原细胞易位剂量-效应曲线为铃形。精原干细胞有敏感性不同的亚群,另外,它的不同细胞周期对诱发易位和细胞死亡的敏感性也不同。大剂量照射时,带易位的细胞大量死亡,使易位率降低;小剂量照射时,表现假直线相关。所以,敏感和不敏感细胞亚群的比例决定着剂量效应曲线型状。小鼠标准核型的变异可影响精母细胞期观察到的精原细胞易位率。已证明:辐射诱发T70H杂合易位(translocation heterozygous)小鼠(T70H/+)精原细胞易位率比诱发正常小鼠的低。本文报导了T_(70)H/+小鼠的剂量效应关系并与正常小鼠进行
A typical radiation-induced mouse spermatogonial translocation dose-response curve was bell-shaped. Spermatogonial stem cells have different subtypes of sensitivity. In addition, the sensitivity of different spermatogonial stem cells to induce translocation and cell death is also different. Large doses of irradiation, with a large number of translocation of cells died, reducing the rate of translocation; low dose irradiation, the performance of false linear correlation. Therefore, the proportion of sensitive and insensitive cell subsets determines the dose response curve shape. Variability in mouse standard karyotype can affect the spermatocyte translocation rate observed at the spermatocyte stage. It has been demonstrated that radiation-induced translocation heterozygous (T70H / +) spermatogonia translocations are lower than those induced in normal mice. This article reports the dose-response relationship of T_ (70) H / + mice and normal mice