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继自体骨髓移植之后,自体外周血干细胞移植(ABSCT)已经成为治疗急性白血病的另一有效方法。特别在我国同基因供髓者缺乏的情况下,发展ABSCT更具有实际应用价值。但在正常状态下外周血干细胞(PBSC)水平仅为骨髓的1％～10％。因此,如何提高外周血干细胞水平,采集到足够的PBSC是进行ABSCT的成功的关键。已知抗肿瘤药物具有对PBSC的扩增作用,但是目前国内常用的几种治疗急性白血病的化疗药物对PBSC的扩
Following autologous bone marrow transplantation, autologous peripheral blood stem cell transplantation (ABSCT) has become another effective treatment of acute leukemia. Especially in our country with the lack of syngeneic donor, the development of ABSCT more practical value. However, peripheral blood stem cell (PBSC) levels are normally only 1% to 10% of bone marrow in normal conditions. Therefore, how to improve the level of peripheral blood stem cells, collecting enough PBSC is the key to the success of ABSCT. Known antitumor drugs have the effect of the expansion of PBSC, but currently several commonly used in the treatment of acute leukemia chemotherapy drugs on PBSC expansion