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Objective:To evaluate the therapeutic efficacy of low-grade glioma (WHO grades Ⅰ-Ⅱ) patients treated with gamma knife radiosurgery and study on the efficacy evaluation method and radiobiological effect.Methods:140 MRI data of 52 patients after gamma knife radiosurgery were analyzed in tumor size,necrosis or cyst formation,radiation-induced edema and MRI contrast enhancement and circumsciption change for therapeutic efficacy was evaluated.Results:The efficiency rate was 84.3%.The salient efficiency rates were 54.3% for total and 30%,36.4%,50%,68%,69.2%,and 73.1% for segmenting,respectively.Aggrandizement of tumor related to MRI contrast enhancement and necrosis or cyst formation.Radiation-induced oedema occurred for 32.7%.The MRI contrast enhancement occurred for 57.7% and showed special lace-like ring while some piece-like.Conclusion:Evaluation by MRI has showed gamma knife radiosurgery is efficient for low-grade glioma.The segmenting salient efficiency rate that increase with time is better for evaluation than the efficiency rate especially for long-term MRI follow-up.Radiobiological effect affect the efficacy evaluation.MRI contrast enhancement appears after therapy and shows special as lace-like ring and partly minificates or vanishes subsequently.