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目的:探讨中西医结合护理管理措施在围绝经期综合征(PMS)患者中的应用及对血清性激素水平的影响。方法:选取妇产科门诊治疗的PMS患者80例,随机分为观察组和对照组各40例。2组患者均予以帕罗西汀片20 mg/次,每天1次,口服。对照组患者予以常规护理管理措施,观察组患者予以中西医结合护理管理措施,2组均干预8周。观察并比较2组干预前后抑郁和焦虑症状及血清促卵泡素(FSH)、雌二醇(E_2)和黄体生成素(LH)水平的变化。结果:干预8周后,2组患者SAS和SDS评分较治疗前明显下降,且观察组下降较对照组更明显,差异均有统计学意义(P<0.05,P<0.01);2组患者血清E_2水平比治疗前明显上升,FSH和LH水平比治疗前明显下降,且观察组上升或下降较对照组更明显,差异均有统计学意义(P<0.05,P<0.01)。结论:中西医结合护理管理措施较常规护理管理措施更能改善PMS妇女的抑郁、焦虑症状,能明显降低血清FSH和LH水平,升高E2水平,从而纠正性激素紊乱。
Objective: To explore the application of integrated traditional Chinese and Western medicine nursing management measures in patients with perimenopausal syndrome (PMS) and its effect on serum sex hormone levels. Methods: Eighty patients with PMS treated by obstetrics and gynecology clinic were randomly divided into observation group (40 cases) and control group (40 cases). Patients in both groups were treated with paroxetine 20 mg once daily orally. Patients in the control group were given routine nursing management measures, and patients in the observation group were treated with integrated traditional Chinese and western medicine. Both groups were given interventions for 8 weeks. The depression and anxiety symptoms and the changes of serum FSH, LH and LH were observed and compared before and after treatment. Results: After 8 weeks of intervention, SAS and SDS scores of two groups were significantly lower than those before treatment, and the decrease of observation group was more obvious than that of control group (P <0.05, P <0.01); The serum of two groups E 2 levels were significantly increased before treatment, FSH and LH levels were significantly lower than before treatment, and the observation group increased or decreased more significantly than the control group, the difference was statistically significant (P <0.05, P <0.01). Conclusion: The integrated traditional Chinese and western medicine nursing management measures can improve depression and anxiety symptoms of PMS women, reduce the level of serum FSH and LH, raise the level of E2, and correct the disorder of sexual hormones.