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目的：研究吲哚美辛（Ｉｎｄ）对关节损伤的影响．方法：检测佐剂性关节炎大鼠（ＡＡ）非致炎侧后足爪容积，ＬＰＳ诱导腹腔巨噬细胞和关节滑膜细胞产生白细胞介素１（ＩＬ１），以及兔滑膜成纤维细胞增殖反应和软骨蛋白多糖的合成．结果：Ｉｎｄ２ｍｇ·ｋｇ－１·ｄ－１ｉｇ９ｄ，可抑制ＡＡ大鼠ｄ１８，ｄ２１，和ｄ２４继发炎症反应，但促进巨噬细胞和滑膜细胞分泌ＩＬ１．Ｉｎｄ１０μｍｏｌ·Ｌ－１体外分别促进ＩＬ１诱导兔滑膜成纤维细胞增殖反应以及抑制关节软骨蛋白多糖合成．结论：Ｉｎｄ不利于关节损伤的修复．
Objective: To study the effect of indomethacin (AD) on joint injury. Methods: The volume of paws of non-inflammation side of adjuvant arthritis (AA) rats was measured. LPS induced interleukin-1 (IL-1) production in peritoneal macrophages and synovial cells, Fibroblast Proliferation and Synthesis of Cartilage Proteoglycan. Results: Ind2mg · kg-1 · d-1ig9d inhibited the secondary inflammation of d18, d21 and d24 in AA rats, but promoted the secretion of IL1 by macrophages and synovial cells. Ind10μmol·L-1 in vitro to promote IL 1 induced rabbit synovial fibroblasts proliferation and inhibition of articular cartilage proteoglycan synthesis. Conclusion: Ind is not conducive to the repair of joint injuries.