论文部分内容阅读
小脑性疾患经常出现静止性和近似运动性震颤.因震颤可造成残废,常常严重的影响日常生活。有关震颤发生的生理生化机制不清。Carrea Mettler提出:震颤不只是严重共济失调的后果,小脑外侧核及其传出路受损与震颤的发生有关。原发性震颤可出现肢体近端和远端的静止性震颤及远端的运动性震颤.Critchley 提出:原发性震颤可能是小脑萎缩的顿挫型.目前已确认,心得安是治疗原发性震颤的有效药物,乙醇对原发性震颤亦有一定疗效。近来 Sabra 等人报告,口服异烟肼(每天800～1200mg)使四例多发性硬化病人的体位性震颤明显减轻。他估计,药物在使γ-氨基丁酸增加的机制上起作用。异烟肼可抑制γ-氨基丁酸氨基移换酶,此酶是γ-氨基丁酸分解过程的第一个酶。异烟肼剂量达
Cerebellar disorders often have quiescent and quasi-motor quills, which can cause disability and often have a serious impact on everyday life. Physiological and biochemical mechanisms for the occurrence of tremor unclear. Carrere Mettler argues that tremor is not just a consequence of serious ataxia, but that the damage to the lateral cerebellar nucleus and its afferent pathway is associated with the occurrence of tremor. Primary tremor can occur in the proximal and distal extremities of resting tremor and distal motility tremor.Critchley proposed: primary tremor may be a setback for cerebellar atrophy has now confirmed that propranolol is the treatment of primary Tremor of the effective drugs, ethanol, also have some effect on the primary tremor. Recently, Sabra et al. Reported that oral isoniazid (800-1200 mg daily) significantly attenuated postural tremor in four patients with multiple sclerosis. He estimates that the drug plays a role in the mechanism that increases gamma-aminobutyric acid. Isoniazid suppresses the gamma-aminobutyrate aminotransferase enzyme, which is the first enzyme in the decomposition of gamma-aminobutyric acid. Isoniazid dose up to