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目的:对比分析阿替普酶与尿激酶治疗急性肺栓塞的临床效果。方法:选取我科48例急性肺栓塞患者,随机分为对照组和实验组两组,对照组24例采用尿激酶溶栓治疗,实验组24例采用阿替普酶溶栓治疗,比较两组临床疗效。结果:治疗24h后,实验组溶栓有效率91.67%,显著高于对照组79.17%(p<0.05);实验组动脉血氧分压、肺动脉收缩压、动脉收缩压均显著优于对照组(p<0.05);两组溶栓后24h出血率比较,无显著差异(p>0.05)。结论:阿替普酶治疗急性肺栓塞效果显著,能够有效改善肺动脉压水平,值得推广。
Objective: To compare and analyze the clinical effect of alteplase and urokinase in the treatment of acute pulmonary embolism. Methods: A total of 48 patients with acute pulmonary embolism in our department were randomly divided into control group and experimental group. 24 cases in control group were treated with urokinase thrombolysis. 24 cases in experimental group were treated with alteplase thrombolysis. Clinical efficacy. Results: After treatment for 24 h, the effective rate of thrombolysis in experimental group was 91.67%, which was significantly higher than that in control group (79.17%, p <0.05). The arterial partial pressure of oxygen, pulmonary artery systolic pressure and arterial systolic pressure in experimental group were significantly better than those in control group p <0.05). There was no significant difference in bleeding rate between the two groups after 24h of thrombolysis (p> 0.05). Conclusion: Altreplase is effective in treating acute pulmonary embolism, which can effectively improve the pulmonary arterial pressure and is worth promoting.