【摘 要】
：
Kosinostatin (KST) contains an uncommon aminopyrrole moiety,whose biosynthesis has remained elusive.Herein,aminopyrrolinic acid,which was generated by an L-ectoine synthase-like enzyme KstB3 via cyclization of L-glutamine,was identified to be the real sub
【机 构】
：
State Key Laboratory of Bio-organic and Natural Products Chemistry,Center for Excellence in Molecula
论文部分内容阅读
Kosinostatin (KST) contains an uncommon aminopyrrole moiety,whose biosynthesis has remained elusive.Herein,aminopyrrolinic acid,which was generated by an L-ectoine synthase-like enzyme KstB3 via cyclization of L-glutamine,was identified to be the real substrate of adenylation enzyme KstB1.Subsequently,a FAD-dependent dehydrogenase KstB4 along with a transglutaminase-like en-zyme KstB6 were also involved in formation of aminopyrrole.These results provided an unusual pathway for 2-aminopyrrole for-mation in KST biosynthesis.
其他文献
Persistent luminescence is an optical phenomenon where solid phosphors can store photoenergy in defects and release the energy by luminescence after stopping excitation.Due to the intriguing optical characteristics,the defect luminescence based persistent
鲁尔玛斑岩型铜(金)矿为冈底斯成矿带西段新发现的斑岩型矿点,目前已发现赋存于石英二长斑岩体中的斑岩型铜矿体1条,赋存于构造破碎带中的热液型脉状金(铜)矿体1条、热液型脉状铜矿体1条.以鲁尔玛含矿斑岩为中心,依次发育钾硅酸盐化、绢英岩化、青磐岩化,表现出斑岩型矿床的典型蚀变分带模式.其中,热液脉体从早到晚被可划分为:钾硅酸盐化脉(A脉)、石英-金属硫化物脉(B脉)以及石英-绿帘石-碳酸盐化脉(D脉).这一新的发现,证实冈底斯成矿带西段具有斑岩型铜(金)矿床的找矿潜力,有望将冈底斯斑岩型铜矿带向西延伸近200
In the context of sustainable development and carbon neutrality,great efforts have been dedicated to the utili-zation of green energy such as sunlight and renewable electricity to tackle problems encountered amid energy-and emission-intensive industries l
Herein is presented a compilation of the main characteristics of maleimide chemistry in developing the precisely controlled polymers,including the design of sequence-controlled polymers,topological poly-mers,and polymeric single-chain nanoparticles.The sy
An oxidative tandem (4+2)-cyclization/aromatization of N-aryl glycine derivatives with electron-deficient alkenes was first achieved using Ru(bpy)3Cl2 as a photocatalyst and TBHP as an oxidant in combination with visible-light irradiation by blue LEDs.One
A highly efficient kinetic resolution of racemic thioanilide atropisomers via C(sp3)-H arylation has been achieved by a hybrid palladi-um catalyst bearing an anionic chiral CoⅢ-complex and a phosphoramidite ligand,leading to both enantioenriched atropisom
Prediction of reaction yields using machine learning (ML) can help chemists select high-yielding reactions and provide prior experi-ence before wet-lab experimenting to improve efficiency.However,the exploration of a multicomponent organic reaction featur
While polystyrene is widely used in daily life as a synthetic plastic,the subsequently selective degradation is still very challenging and highly required.Herein,we disclose a highly practical and selective reaction for the catalytically efficient oxidati
四川省大地构造演化研究已有百余年的历史,不同时期、不同学派在不同的尺度上提出了不同的大地构造单元划分方案,其中仍存在诸多争议.本文结合近30年来四川省特别是造山带地区开展的蛇绿岩和洋板块地层等调查和研究成果,以李廷栋所提出的洋板块地质学理念为指导思想,以区域主构造事件形成的优势大地构造相的时空结构组合和存在状态为基本原则,划分出秦-祁-昆造山系、勉县-略阳对接带、北羌塘-三江造山系以及扬子克拉通4个一级构造单元,包括11个二级构造单元和24个三级构造单元.
The first asymmetric decarboxylative[3+2]-cycloaddition of ethynyl indoloxazolidones with carboxylic acids has been developed un-der synergistic catalysis of copper and chiral Lewis base.This protocol provides a direct and modular approach to biologically