论文部分内容阅读
1970年以来骨髓移植已有卓有成效的进展。如今骨髓移植不仅用于治疗多种血液病,还应用于非造血系统疾病,在白血病进展期的患者其成功率为15%,对未曾输血的再生障碍性贫血患者为80%。白血病占所有骨髓移植总数的70%以上。据最佳疗效资料统计,急性髓细胞白血病(AML)首次缓解期,急性淋巴细胞白血病(ALL)首次缓解期以及慢性粒细胞白血病(CML)的慢性期,骨髓移植后的5年无病生存期约50%。那么,今后若干年内对骨髓移植疗效改观的展望又是如何呢? 首先,要考虑骨髓移植失败的原因。国际骨髓移植登记中心的资料表明,移植后实际复发率为:
Bone marrow transplantation has made remarkable progress since 1970. Today, bone marrow transplantation is used not only for the treatment of a variety of hematological diseases but also for nonhematopoietic disorders, with a success rate of 15% in patients with advanced leukemia and 80% in patients with aplastic anemia who have not transfused. Leukemia accounts for more than 70% of all bone marrow transplants. According to the best curative effect data, the first remission of acute myeloid leukemia (AML), the first remission of acute lymphoblastic leukemia (ALL) and the chronic phase of chronic myeloid leukemia (CML), the 5 year disease free survival after bone marrow transplantation About 50%. So, in the next few years on the efficacy of bone marrow transplantation prospect is how? First, we must consider the reasons for the failure of bone marrow transplantation. The International Marrow Transplant Registration Center data show that the actual recurrence rate after transplantation is: