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鼠脑中铝能抑制细胞质内及线粒体内己糖激酶的活性,其C_(50)值在4和9UM之间。在生理性水平镁(0.5mM)存在下,铝在弱陵(PH6.8)或弱碱(PH7.2～7.5)中起作用。当镁在饱和情况下(8mM)则能拮抗细咆质及线粒休中铝对己精激酶活性的抑制作用。检验说明铝对其它酶活性的抑制作用不大敏感,铝对磷酸果糖激酶的IC50为1.8mM,对乳酸脱氧酶的IC50则为0.4mM。10～600uM的铝能刺激丙酮酸激酶的活性。在鼠脑提取液中铝
Aluminum in rat brain inhibits intracellular and mitochondrial hexokinase activities with C_ (50) values between 4 and 9 μM. Aluminum plays a role in Wellingol (PH6.8) or weak base (pH7.2 ~ 7.5) in the presence of physiologic levels of magnesium (0.5 mM). Magnesium, at saturation (8 mM), was able to antagonize the inhibitory effect of aluminum on spermine kinase activity in sarcoplasmic reticulum and in mitochondria. Tests showed that aluminum was less sensitive to inhibition of other enzyme activities, with IC50 of 1.8 mM for phosphofructokinase and 0.4 mM for lactate dehydrogenase. Aluminum from 10 to 600 uM stimulates pyruvate kinase activity. Aluminum in rat brain extract