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目的:观察卡前列素氨丁三醇两种给药方式用于产后出血的疗效及安全性。方法:285例产后出血产妇按随机数字表法分为对照组(143例)和试验组(142例)。对照组产妇给予卡前列素氨丁三醇注射液250μg手臂三角肌肌内注射;试验组产妇给予同等剂量的卡前列素氨丁三醇注射液宫颈注射。两组产妇均在第三产程后一次给药。观察两组产妇临床疗效、2 h内子宫出血量、阴道出血量以及产后不良反应发生率。结果:给药后两组产妇产后出血量均<400 ml,未超过产后大出血的标准,差异无统计学意义(P>0.05)。试验组产妇的子宫出血量显著高于对照组,阴道出血量显著低于对照组,差异有统计学意义(P<0.05);试验组不良反应发生率(4.90%)与对照组(6.31%)比较,差异无统计学意义(P>0.05)。结论:子宫收缩乏力产妇产后出血采取手臂三角肌肌内注射疗效较好,其他产妇产后出血采取宫颈注射疗效较好,且不良反应均较低。
Objective: To observe the curative effect and safety of the two kinds of carboprost trometamol for postpartum hemorrhage. Methods: 285 cases of postpartum hemorrhage were randomly divided into control group (143 cases) and experimental group (142 cases). In the control group, the pregnant women were given carboprost trometamol injection 250μg intramuscular deltoid muscle intramuscular injection; the test group were given the same amount of carboprost trometamol injection cervical injection. Two groups of mothers were given once after the third stage of labor. Observe the clinical efficacy of two groups of maternal, uterine bleeding within 2 h, the amount of vaginal bleeding and the incidence of postpartum adverse reactions. Results: The postpartum hemorrhage volume of both groups was less than 400 ml after administration, which did not exceed the standard of postpartum hemorrhage. The difference was not statistically significant (P> 0.05). The amount of uterine bleeding in the experimental group was significantly higher than that in the control group, and the amount of vaginal bleeding was significantly lower than that in the control group (P <0.05). The incidence of adverse reactions in the experimental group (4.90%) and the control group (6.31% The difference was not statistically significant (P> 0.05). CONCLUSION: Intra-uterine injection of arm deltoid muscle by postpartum hemorrhage with uterine atony malabsorption is effective, and other maternal postpartum hemorrhage with cervix injection has better curative effect and lower adverse reactions.