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气道重塑是支气管哮喘的重要特征之一,大量研究表明,生长因子、细胞因子、炎性介质和酶等多种因素参与气道重塑。目前,部分细胞因子对气道重塑的影响机制已相对明确,而凝血酶对气道重塑的影响研究目前很少,本文就近年来凝血酶与气道重塑的研究进展阐述如下。
Airway remodeling is one of the most important characteristics of bronchial asthma. A large number of studies have shown that many factors such as growth factors, cytokines, inflammatory mediators and enzymes are involved in airway remodeling. At present, some cytokines on airway remodeling mechanism has been relatively clear, and the impact of thrombin on airway remodeling is currently little research on the thrombin in recent years and airway remodeling are as follows.