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目的:探讨丹红注射液对急性心肌梗死患者行急诊PCI治疗后炎症因子的影响。方法:选取2011年1月—2012年1月,心内科住院急性心肌梗死并接受PCI患者118例,分为常规治疗组、丹红组。常规治疗组术后皮下注射低分子肝素钠(5000U/12h),口服硝酸酯类、辛伐他汀、拜阿斯匹林、氯吡格雷、ACEI或ARB;丹红组在术后常规治疗基础上加用丹红注射液(菏泽步长制药有限公司)20mL,加入5%葡萄糖或生理盐水250mL静脉输注,术前及术后7天测定hs-CRP、IL-6、TNF-α浓度。结果:常规治疗组PCI术后hs-CRP、IL-6、TNF-α浓度较PCI术前增高,差异有统计学意义(P<0.05);丹红组PCI术后hs-CRP、IL-6、TNF-α浓度较同组PCI术前降低,差异有统计学意义(P<0.05);丹红组PCI术后的hs-CRP、IL-6、TNF-α浓度与常规治疗组PCI术后同期比较降低,差异也有统计学意义(P<0.05)。结论:丹红注射液可降低PCI术后炎症因子的产生。
Objective: To investigate the effect of Danhong injection on inflammatory factors after emergency PCI in patients with acute myocardial infarction. Methods: From January 2011 to January 2012, 118 patients with acute myocardial infarction who were hospitalized for cardiology and received PCI were divided into routine treatment group and Danhong group. The conventional treatment group was subcutaneously injected with low molecular weight heparin sodium (5000U / 12h), oral nitrates, simvastatin, aspirin, clopidogrel, ACEI or ARB after operation. On the basis of routine treatment 20mL of Danhong injection (Heze Buchang Pharmaceutical Co., Ltd.) was added. The concentration of hs-CRP, IL-6 and TNF-α was measured preoperatively and 7 days after operation by adding 250mL of 5% glucose or saline. Results: The levels of hs-CRP, IL-6 and TNF-α in PCI group after PCI were significantly higher than those in PCI group (P <0.05) (P <0.05). The concentrations of hs-CRP, IL-6 and TNF-α in Danhong group after PCI were significantly lower than those in the control group Compared with the same period, the difference was also statistically significant (P <0.05). Conclusion: Danhong injection can reduce the production of inflammatory cytokines after PCI.