【摘 要】
：
Cell adhesion on a supported lipid bilayer(SLB)functionalized with ligand proteins is a widely-used cell-mimetic model for the study of the trans receptor-ligand interaction that mediates the adhesion,and has been shown to play an important role in unrave
【机 构】
：
State Key Laboratory of Nonlinear Mechanics(LNM)and Beijing Key Laboratory of Engineered Constructio
【出 处】
：
中国科学：物理学 力学 天文学（英文版）
论文部分内容阅读
Cell adhesion on a supported lipid bilayer(SLB)functionalized with ligand proteins is a widely-used cell-mimetic model for the study of the trans receptor-ligand interaction that mediates the adhesion,and has been shown to play an important role in unravel-ling the molecular players in cell adhesion.Experimental studies of such cell-SLB adhesion systems often assume that there is no cis interactions between the ligands.An important question remains whether the cis-interaction affects the trans receptor-ligand interaction.Using a statistical-mechanical model and Monte Carlo simulations with biologically relevant parameters,we find that the attractive cis-interaction of strength 1 kBT between adjacent ligands on the SLB can lead to an amplification of both the affinity and cooperativity of the receptor-ligand binding,thereby facilitating the phase separation within the adhering cell membrane.In contrast,the adhesion system is less sensitive to the repulsive cis-interaction between adjacent ligands on the SLB.Our results suggest that the ligand-ligand cis-interaction should be carefully considered in the cell-SLB adhesion experiments.
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