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血纤维蛋白溶酶原(Fiasminogen)受到组织和体液中的蛋白酶激活形成血纤维蛋白溶酶。血纤维蛋白溶酶涉及各种生理和病理现象,包括血纤维蛋白溶解作用、血纤维蛋白原溶解作用、控制血凝、补体活化、激肽产生、激素原水解、组织重建和细胞恶性肿瘤的转化等。血纤维蛋白溶酶能溶解血纤维蛋白凝块并将它的前体分子血纤维蛋白原转化为可溶性肽,对防止血栓形成和保持血流畅通具有重要意义。近来发现,血纤维蛋白溶酶原的激活物由一些迁移性或侵袭性细胞产生,表明血纤维蛋白溶酶在组织重建和细胞迁移
Fiasminogen is activated by proteases in tissues and body fluids to form plasmin. Plasmin involves a variety of physiological and pathological phenomena including fibrinolysis, fibrinogenolysis, blood clotting control, complement activation, kininogenesis, pro-hormone hydrolysis, tissue remodeling and the transformation of cell malignancies Wait. Plasmin, which dissolves the fibrin clot and transforms its precursor molecule fibrinogen into soluble peptides, is important for preventing thrombosis and maintaining blood flow. It has recently been discovered that plasminogen activators are produced by some migratory or invasive cells, suggesting that plasmin in tissue remodeling and cell migration