论文部分内容阅读
为了研究急性药物高泌乳素血症对健康男子垂体-性腺的影响,我们对10例31～38岁男子作研究。被试者口服灭吐灵15mg,每8小时1次,连服7天半。分别于服药前、服药后第4、8、10天上午8:00取静脉血,测定PRL、LH、FSH、T、DHT及E_2。用灭吐灵(45mg/天)后第4、8天血清PRL从基础值309.29±28.67μu/ml上升到1260.5±124.08和1525.0±85.69μu/ml,分别是基础值的408％和493％,比基础值显著增高(P<0.01)。服药后第10天(即停药2.5天)血清PRL恢复到基础值以下。在急性高泌乳素血症期间,血清LH、FSH、T、DHT和E_2有所波动,但无统计学意义(P>0.05)。
To investigate the effect of acute hyperprolactinemia on the pituitary gonads in healthy men, we conducted a study of 10 men aged 31-38 years. The subjects were oral chlorothalonol 15mg, every 8 hours 1, even for 7 days and a half. Venous blood samples were collected before treatment, on the 4th, 8th and 10th days after taking the medication at 8:00 am, respectively. PRL, LH, FSH, T, DHT and E_2 were measured. Serum PRL increased from baseline values of 309.29 ± 28.67μu / ml to 1260.5 ± 124.08 and 1525.0 ± 85.69μu / ml on days 4 and 8 after treatment with metoclopramide (45mg / day), representing 408% and 493% of baseline, respectively, Than the base value was significantly higher (P <0.01). Serum PRL recovered to below basal values on day 10 (ie discontinuation for 2.5 days). During acute hyperprolactinemia, serum LH, FSH, T, DHT and E 2 fluctuated, but not statistically significant (P> 0.05).