【摘 要】
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Platinum-based chemotherapy is used for non-small cell lung cancer (NSCLC).However,it has side effects and minimum efficacy against lung cancer metastasis.In th
【机 构】
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School of Pharmacy Tongji Medical College, Huazhong University of Science and Technology, Wuhan 4300
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Platinum-based chemotherapy is used for non-small cell lung cancer (NSCLC).However,it has side effects and minimum efficacy against lung cancer metastasis.In this study,platinum-curcumin complexes were loaded into pH and redox dual-responsive nanoparticles (denoted as Pt-CUR@PSPPN) to facilitate intracellular release and synergistic anti-cancer effects.Pt-CUR@PSPPN was prepared by a nano-precipitation method and had a diameter of ～ 100 nm.The nanoparticles showed increased anticancer effects both in vivo and in vitro.In addition,Pt-CUR@PSPPN blocked PI3K/AKT signal transduction pathway and inhibited MMP2 and VEGFR2,resulting in enhanced anti-metastatic activity.Furthermore,reduced side effects were also observed.In conclusion,Pt-CUR@PSPPN provided a novel and attractive therapeutic strategy for NSCLC.
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