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缺血性肾损害可通过血栓素(TX)合成的抑制加以预防,该预防作用被认为是以高前列腺素(PG)/TXA_2比率为前提。本文观察给予扩血管性PG提高PG/TX比率能否减弱缺血性肾损害。取60只成年雄性大鼠,置颈静脉导管用以输注药物和液体。行右肾切除术,同时分离左肾蒂关闭血流45分钟造成肾缺血,在血管夹放松前10分钟及此后2小时内,分别给予:①生理盐水;②布洛芬(Ibu)③PGI_2;④PGE_1;⑤Ibu+PGI_2;⑥Ibu+PGE_1。对照动物左肾蒂不予关闭,其余处理均与肾缺血动物相同。肾缺血45分钟,放松血管夹5分钟,抽取左肾静脉血2
Ischemic renal damage can be prevented by inhibition of thromboxane (TX) synthesis, which is presumed to be at a high PG / TXA2 ratio. This article observes whether vasodilator PG can improve the PG / TX ratio can reduce ischemic renal damage. Sixty adult male rats were dosed with a jugular catheter for the infusion of medication and fluids. Right nephrectomy was performed and the left renal pedicle was occluded for 45 minutes to cause renal ischemia. Within 10 minutes before vascular clamp relaxation and within 2 hours thereafter, were given: ① saline; ② ibu; ③ PGI_2; ④ PGE_1; ⑤ Ibu + PGI_2; ⑥ Ibu + PGE_1. Control animals left kidney pedicle will not be closed, the rest of the treatment and renal ischemia animals are the same. 45 minutes of renal ischemia, relax the vascular clamp for 5 minutes, and extract the left renal vein 2