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新发现的Ｃ型利钠利尿肽（ＣＮＰ）是心房利钠利尿肽（ＡＮＰ）家族中的一员，由内皮细胞产生，和血管平滑肌细胞ＡＮＰＲ－Ｂ受体结合，使外周静脉扩张和回心血量减少，导致心脏充盈压和心输出量降低，这是降压的主要机理，该肽无利钠利尿作用。ＣＮＰ的作用机制与ｃＧＭＰ（第二信使）没有关系。心衰时，血管对ＣＮＰ的反应性不变。因此，ＣＮＰ在来源、作用部位、作用特点、作用机制及病理状态下的反应性等与熟知的ＡＮＰ均有显著不同。
The newly discovered C-type natriuretic peptide (CNP), a member of the atrial natriuretic peptide (ANP) family, is produced by endothelial cells and binds to the ANPR-B receptor of vascular smooth muscle cells, causing peripheral venous dilatation and rewarming This decrease in volume leads to a decrease in cardiac filling pressure and cardiac output, which is the primary mechanism of antihypertensive activity and does not have natriuretic and diuretic effects. The mechanism of CNP has nothing to do with cGMP (second messenger). Heart failure, vascular reactivity to CNP unchanged. Therefore, CNP is significantly different from the well-known ANP in origin, site of action, functional characteristics, mechanism of action, and reactivity in pathological conditions.