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目的:对菊科千里光属植物菊叶千里光Senecio chrysanthemoides全草乙醇提取物的乙酸乙酯部位的化学成分进行系统的研究。方法:采用硅胶、Sephadex LH-20柱色谱、薄层制备和制备型高效液相色谱方法进行分离;应用NMR和MS等波谱方法鉴定化合物的结构。结果:从菊叶千里光的乙酸乙酯部位分离得到25个化合物,分别鉴定为千里光菲林碱(1),千里光碱(2),1,2-dihydrocacalohastine(3),桉叶醇-4(15)-烯-1β,6α-二醇(4),7,11,15-三甲基-3-亚甲基十六烷-1,2-二醇(5),款冬二醇3-O-棕榈酸酯(6),马尼拉二醇3-O-棕榈酸酯(7),款冬二醇(8),马尼拉二醇(9),β-香树脂醇(10),α-香树脂醇(11),白桦脂醇(12),loranthol(13),(+)-丁香树脂酚(14),1-羟基-4-酮-环己烯-1-乙酸酯(15),2,6-二甲氧基对苯醌(16),豆甾-5,22-二烯-3β-羟基-7-酮(17),豆甾-5,22-二烯-7-酮(18),豆甾-4-烯-3-酮(19),豆甾-4,22-二烯-3-酮(20),β-谷甾醇(21),豆甾醇(22),胡萝卜苷(23),十一烷酸甘油酯(24)和十一烷酸甲酯(25)。讨论:化合物5～9,13,17～20和24均为首次从该属植物中分离得到。
OBJECTIVE: To systematically study the chemical constituents of the ethyl acetate fraction of the ethanol extract of Senecio chrysanthemoides, a plant belonging to the genus Compositae. Methods: Silica gel, Sephadex LH-20 column chromatography, TLC and preparative HPLC were used for the separation. The structures of the compounds were identified by NMR and MS. Results: Twenty-five compounds were isolated from the ethyl acetate fraction of Chrysalis, and were identified as seretide (1), seretide (2), 1,2-dihydrocarbalohastine (15) -ene-1β, 6α-diol (4), 7,11,15-trimethyl-3- methylenehexadecane-1,2-diol (6), Maniladiol 3-O-palmitate (7), Paraquat (8), Maniladiol (9), β-amyrin (10), α-fragrant resin Alcohol (11), betulin (12), loranthol (13), (+) - syringphenol (14), 1 -hydroxy-4-keto- cyclohexene-1 -acetate Dimethoxy p-benzoquinone (16), stigmasterol-5,22-dien-3β-hydroxy-7-one (17), stigmasterol-5,22-dien-7-one (20), β-sitosterol (21), stigmasterol (22), daucosterol (20), stigmasterol 23), undecanoate (24) and undecylenic acid methyl ester (25). Discussion: Compounds 5 ~ 9, 13, 17 ~ 20 and 24 were isolated from this genus for the first time.