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目的探讨妊娠期肝内胆汁酸淤积症(ICP)妊娠结局与血清胆汁酸水平的相关联系。方法根据血清胆汁酸水平将88例ICP患者分为A组15~30μmol/L;B组>30μmol/L,比较两组妊娠结局。结果血清胆汁酸与不良围产结局的发生关系密切,两组中血清胆汁酸值越高,其不良围产结局发生率越高,而导致血清胆汁酸升高的不同疾病之间差异无统计学意义。结论 ICP患者实验室检查胆酸是重要敏感的指标,有胆酸明显升高的患者出现妊娠结局异常的概率明显增加,对胆酸升高明显的ICP患者,应注意加强监护并能适时终止妊娠。
Objective To investigate the correlation between pregnancy outcome of intrahepatic bile acidosis (ICP) and serum bile acid level during pregnancy. Methods According to the level of serum bile acid, 88 patients with ICP were divided into 15 ~ 30μmol / L group A and 30μmol / L group B, and the pregnancy outcome was compared between the two groups. Results Serum bile acid was closely related to the incidence of adverse perinatal outcomes. The higher the serum bile acid value was, the higher the incidence of adverse perinatal outcomes was. Serum bile acid was not significantly different among different diseases significance. CONCLUSION: Cholesteric acid is an important and sensitive index in the laboratory of ICP patients. The probability of abnormal pregnant outcome is significantly increased in patients with markedly increased bile acid. In ICP patients with obvious increase of bile acid, care should be taken to strengthen supervision and timely termination of pregnancy .