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目的探讨血清降钙素原在小儿早期中枢神经系统感染鉴别诊断中的价值。方法 200例中枢神经系统感染患儿,其中急性细菌性脑膜炎患儿100例,作为细菌组。急性病毒性脑炎患儿100例,作为病毒组。对患儿的血清和脑脊液降钙素原水平进行检测,探讨两者之间的相关性。结果细菌组患儿入院时血清降钙素原为(18.96±9.32)ng/ml,脑脊液降钙素原为(0.98±0.28)ng/ml,明显高于病毒组的(0.59±0.31)、(0.24±0.12)ng/ml(P<0.05)。治疗后,细菌组患儿的血清降钙素原为(6.85±3.45)ng/ml,明显高于病毒组患儿的(0.47±0.27)ng/ml(P<0.05)。结论在对小儿早期中枢神经系统感染类疾病鉴别诊断的过程中,使用血清降钙素原的手段能够起到较好诊断效果,在临床对小儿中枢神经系统感染患儿的鉴别诊断时有着极高应用价值,值得推广。
Objective To investigate the value of serum procalcitonin in early diagnosis of central nervous system infection in children. Methods 200 cases of central nervous system infection in children, including 100 cases of acute bacterial meningitis in children, as a bacterial group. 100 cases of acute viral encephalitis in children, as a virus group. The levels of procalcitonin in serum and cerebrospinal fluid of children were detected to explore the correlation between the two. Results Serum procalcitonin (18.96 ± 9.32) ng / ml and cerebrospinal fluid procalcitonin (0.98 ± 0.28) ng / ml were significantly higher in the bacterial group than those in the virus group (0.59 ± 0.31, 0.24 ± 0.12) ng / ml (P <0.05). After treatment, the serum procalcitonin (6.85 ± 3.45) ng / ml in the bacterial group was significantly higher than that in the virus group (0.47 ± 0.27) ng / ml (P <0.05). Conclusion In the early diagnosis of central nervous system diseases in children during the differential diagnosis, the use of serum procalcitonin can play a better diagnostic results in children with clinical diagnosis of children with central nervous system infection has a very high Application value, it is worth promoting.