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心得安与其他药物并用时,有的可产生协同作用,有的则产生不良反应。现扼要概述。单独用心得安降压效果为52%～65%,且可使末梢阻力增加。如与血管扩张药及利尿药并用其降压疗效可提高达92%,并可减少或抵销各自的副作用。因为单独使用利尿降压药促使儿茶酚胺、血浆肾素和游离脂肪酸增多,并降低血钾浓度。而单独使用血管扩张药(如肼苯哒嗪)时,除直接舒张血管平滑肌,降低外周阻力和动脉压外,尚可阻断α-受体,兴奋β-受体,并引起心率加快和心排出量增高等副作用。心得安则可降低儿茶酚胺、血浆肾素和游离脂肪酸、阻断β-受体,并且不影响血浆容量和血小板聚性。Bauer指出,在合并使用双氢克尿塞和心得安后,引起血浆极低密度脂蛋白、甘油三酯、
When peace of mind and other drugs and use, some can produce synergy, while others have adverse reactions. Now a brief overview. Antihypertensive effect alone with antihypertensive effect of 52% to 65%, and can increase distal resistance. Such as vasodilators and diuretics with its antihypertensive effect can be increased up to 92%, and can reduce or offset their own side effects. Because of the use of diuretic antihypertensive drugs to promote catecholamine, plasma renin and free fatty acids increased, and lower serum potassium concentrations. When vasodilator alone (such as hydralazine), in addition to direct relaxation of vascular smooth muscle, reducing peripheral resistance and arterial pressure, it can block the α-receptor, β-receptor excited, and cause heart rate and heart rate Excretion increased side effects. Adiponaxan can reduce catecholamines, plasma renin and free fatty acids, blocking beta-receptors, and does not affect plasma volume and platelet aggregation. Bauer pointed out that the combined use of hydrochlorothiazide and propranolol causes very low-density plasma lipoproteins, triglycerides,