论文部分内容阅读
获得性免疫缺陷综合疗(AIDS)出现于1981年中期,它使得人们能够窥察免疫系统功能和癌症的起源,其病因学是一种名为HTLV—3/LAV细胞致病性人T—淋巴细胞趋向性反转录病毒。这种病毒表现为对辅助T细胞/诱导下细胞亚型(T_4或Leu3)的选择性感染。患者的免疫系统表现有:显著的淋巴细胞减少症,伴有辅助细胞对抑制细胞的比例降低;T—淋巴细胞功能失调,诸如对促细胞分裂剂及抗原的增殖反应降低,病毒特异性的细胞毒淋巴细胞功能降低和对B—淋巴细胞的辅助能力降低;B—淋巴细胞功能失调和自然杀伤细胞(NK)活性降低。基本的免疫缺陷是发生机合感染和本综合症特征性肿瘤的共同基础。 AIDS病人发生的肿瘤(主要是Kaposi氏肉瘤),1/3为男性同性恋者,而异性恋者仅占5～7％,这提示与同性恋有关的协同因素和AIDS病人的肿瘤
Acquired immunodeficiency syndrome (AIDS) emerged in mid-1981, enabling one to look at the immune system’s function and the origin of cancer, a etiology of a pathogenic human T-lymphoid cell called HTLV-3 / LAV Cell-tropic retroviruses. This virus appears to be a selective infection of helper T cells / induced subtypes (T_4 or Leu3). The patient’s immune system manifests itself with significant lymphopenia accompanied by a decrease in the proportion of helper cells to suppressor cells; dysfunctional T-lymphocytes such as reduced proliferative response to mitogenic agents and antigens, virus-specific cells Reduced lymphocytic function and reduced ability to support B-lymphocytes; B-lymphocyte dysfunction and decreased natural killer (NK) activity. The basic immunodeficiency is the common basis for the development of the synaptic infection and the characteristic tumors of this syndrome. Tumors in AIDS patients (mainly Kaposi’s sarcoma), 1 in 3 male homosexuals, and heterosexuals only 5 to 7%, suggesting a link with homosexuality and AIDS patients’ tumors