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高钾停跳液是临床最常用的停跳液之一,但其心肌保护机理尚未完全清楚。本文以大鼠离体灌流心脏为模型,探讨心肌缺血停跳后给高钾溶液(22mmol/L)的心肌保护作用及其机理。心肌缺血40min后再灌注20min时,心肌收缩幅度(CA)仅恢复到原来的17.4±5.5%,而高钾组CA能恢复到85.3±5.3%(P<0.01),表明高
High-potassium cardioplegia is one of the most commonly used clinical cardioplegia, but the mechanism of myocardial protection is not yet fully understood. In this study, isolated rat perfused heart was used as a model to investigate the myocardial protective effect and mechanism of hyperkalemic solution (22 mmol / L) after myocardial ischemia and cardioplegia. Myocardial contractility (CA) recovered only to 17.4 ± 5.5% of the original after 40 minutes of reperfusion and 40.3 ± 5.3% (P <0.01) of hyperkalemia, indicating high