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目的探讨围手术期腹腔内化疗联合应用IL-2和IFN-γ对胃癌患者预后的影响。方法将行胃癌根治治疗的患者60例随机分成三组,每组20例。A组:术前2d及术后3d腹腔内灌注5-FU、cDDP、IL-2和IFN-γ混合液,B组术后3d腹腔内灌注上述混合液,C组术后3d腹腔内灌注5-FU、cDDP混合液。检测化疗后外周血Th亚群变化、NK细胞数量及FCC;评价治疗中各组化疗的副反应及化疗后的治疗有效率和生存率。结果A组患者在细胞免疫、治疗有效率、肿瘤细胞检出率与B、C组有统计学差异(P<0·05),各组副反应无统计学差异(P>0·05)。结论术后IPC联合应用IL-2和IFN-γ具有一定的临床应用价值。
Objective To investigate the effect of intraperitoneal chemotherapy combined with IL-2 and IFN-γ on the prognosis of gastric cancer patients. Methods Sixty patients undergoing radical gastrectomy were randomly divided into three groups with 20 patients in each group. In group A, intraperitoneal infusion of 5-FU, cDDP, IL-2, and IFN-γ were intraperitoneally administered 2 days before and 3 days after surgery. In group B, the above mixture was perfused intraperitoneally 3 days after surgery. In group C, intraperitoneal infusion was performed 3 days after surgery. -FU, cDDP mixture. The changes of Th subsets, NK cells, and FCC in peripheral blood were measured after chemotherapy. The side effects of chemotherapy in each group and the treatment efficiency and survival rate after chemotherapy were evaluated. Results There was a statistically significant difference between group B and C and group B in the immunosuppression of group A (P<0.05). There was no statistical difference between the groups (P>0.05). Conclusion Postoperative IPC combined with IL-2 and IFN-γ has a certain clinical value.