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从人胎盘分离出的SP-1是绒毛膜合体滋养层细胞分泌的产物,并进入母体血循环中。未受孕的妇女血中检测不出SP-1,但滋养层肿瘤病人血中易检测出SP-1。在妊娠母体血清和羊水中SP-1浓度持续增加至妊娠34周,羊水中SP-1浓度大约是母血清中的1～3%,两者呈正相关。检测SP-1水平对异位妊娠、先兆性流产、宫内生长延迟、成熟或未成熟的低体重胎儿等是一有用的参数,同时在一定程度上SP-1值能反映胎盘功能,但此类研究报道甚少。在Meckel综合征和三倍体胎儿的妊娠中,发
SP-1 isolated from human placenta is a product secreted by chorionic trophoblast cells and enters the maternal blood circulation. SP-1 was undetectable in the blood of un-pregnant women, but SP-1 was easily detected in the blood of trophoblastic tumor patients. The concentration of SP-1 in the pregnant maternal serum and amniotic fluid continuously increased to 34 weeks of gestation, and the concentration of SP-1 in amniotic fluid was about 1 to 3% of that in the maternal serum. Detection of SP-1 levels is a useful parameter for ectopic pregnancy, threatened abortion, delayed intrauterine growth, mature or immature low-birth-weight fetuses and, to some extent, SP-1 values reflect placental function, but Little research reports. In Meckel syndrome and triploid fetus pregnancy, hair