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采用含胆固醇(1％)和胆盐(0.25％)的合成饲料喂饲SD大鼠12周,诱发高胆固醇血症的同时,加入含84.8％葡甘露聚糖的魔芋精粉,三个实验组加入量占饲料重分别为2.5、5.0、10.0％,观察降低血清和肝胆固醇作用。经酶法测定胆固醇含量和肝组织病理学检查结果表明,魔芋多糖对摄入高胆固醇饲料的大鼠,具有明显的降胆固醇作用,加入5.0％喂饲四周即出现显著效果,12周时降至正常组水平。肝组织学检查表明具有明显的抗脂肝作用,对Ca、Fe、Zn、Cu的吸收利用未见不良影响。
SD rats were fed with synthetic diets containing cholesterol (1%) and bile salts (0.25%) for 12 weeks to induce hypercholesterolemia. At the same time, konjac flour containing 84.8% glucomannan was added. Three experimental groups Addition amount accounted for feed weight were 2.5,5.0,10.0%, observed to reduce serum and hepatic cholesterol. Enzymatic determination of cholesterol content and liver histopathological examination results showed that konjac polysaccharides in rats fed high cholesterol feed has a significant cholesterol-lowering effect, adding 5.0% feeding four weeks that a significant effect, 12 weeks reduced to Normal group level. Liver histological examination showed significant anti-lipoidal effects and no adverse effects on the absorption and utilization of Ca, Fe, Zn and Cu.