论文部分内容阅读
氨基导眠能(Aminoglutethimide;简写AG)是安眠药导眠能的衍生物,其安眠作用较导眠能为弱,而抗惊厥作用较后者为强。此药开始用于治疗癫痫,在使用过程中,发现此药可引起肾上腺皮质机能减退。进一步研究证实此药可阻碍肾上腺皮质激素的合成。目前此药用于治疗肾上腺皮质机能亢进症和晚期乳癌。氨基导眠能的化学名是α-乙基-α-对氨苯基-戊二酸亚胺(图1)。氨基导眠能对肾上腺皮质的影响一、对肾上腺皮质激素合成的影响 (一)阻碍胆固醇转变为孕烯醇酮用肾上腺匀浆和放射性胆固醇一起保温,并加入生成
Aminoglutethimide (abbreviated as AG) is a hypnotic derivative of hypnotic, which has less hypnotic effect than sleep-inducing agent and stronger anticonvulsant effect than the latter. The drug started for the treatment of epilepsy, during use, found that the drug can cause adrenal dysfunction. Further studies confirm that the drug can hinder the synthesis of adrenocorticotropic hormone. This medicine is currently used to treat adrenocortical hyperkineosis and advanced breast cancer. The chemical name of amino-insomnia is α-ethyl-α-p-aminophenylglutarimide (Figure 1). Aminopramine can affect the adrenal cortex First, the effects on adrenocorticotropic hormone synthesis (A) hinder the conversion of cholesterol to pregnenolone Adrenal gland homogenates and incubated with radioactive cholesterol, and added to generate