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研究颅外生长的胶质母细胞瘤能否转移以及ＣＤ４４ｖ对它们转移能力的影响。利用基因转染技术，将自发表达ＣＤ４４ｖ（ｍｅｔａ－１）的载体导入转移力较低的大鼠胶质瘤ＲＧ２细胞内，并对有或无ＣＤ４４ｖ表达的ＲＧ２细胞做系统的实验性转移观察。结果发现，与无ＣＤ４４ｖ表达的母系ＲＧ２细胞（ＲＧ２－ｍ）相比，ＣＤ４４ｖ的转染子ＲＧ２－ａ的生长指标和形态学特点并无明显改变；但ＲＧ２－ａ在荷瘤大鼠体内转移出现的时间明显提前，在单位时间内，受累器官的数量增加和破坏程度更为严重。研究结果证实：颅外生长的胶质母细胞具有自发转移能力，ＣＤ４４ｖ可明显提高ＲＧ２细胞的转移效率。ＣＤ４４ｖ做为转移促进因子在肿瘤的生长和扩散中起重要的作用
To investigate whether extracranial glioblastoma growth can be transferred and the effect of CD44v on their metastatic ability. Using a gene transfection technique, a vector expressing spontaneously CD44v (meta-1) was introduced into rat glioma RG2 cells with low metastasis, and a systematic metastatic observation of RG2 cells with or without CD44v expression was performed. As a result, it was found that the growth and morphological characteristics of the transfectant RG2-a of CD44v were not significantly changed compared with maternal RG2 cells (RG2-m) without CD44v expression; however, RG2-a metastasized in tumor-bearing rats. The time of appearance was obviously advanced. In the unit time, the number of affected organs increased and the degree of destruction was even more serious. The results of the study confirmed that extracranial glioblastoma cells have the ability to spontaneously metastasize, and CD44v can significantly increase the metastasis efficiency of RG2 cells. CD44v plays an important role in tumor growth and proliferation as a metastasis promoting factor