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目的 探讨端粒酶活性和口腔鳞癌发生、发展的关系。方法 采用TRAP -PCR -ELISA法对 32例口腔鳞癌标本、1 5例癌旁组织和 1 0例正常口腔粘膜组织进行端粒酶活性检测和分析。结果 口腔鳞癌组织中端粒酶活性值显著高于癌旁组织和正常组织 (P <0 .0 5)。端粒酶在口腔鳞癌标本中阳性检出率 71 .87% ,显著高于癌旁组织和正常组织 (P <0 .0 1 ) ,且和鳞癌的病理分级及有无颈淋巴结转移密切相关。结论 端粒酶活性和口腔鳞癌的发生、发展有密切关系
Objective To investigate the relationship between telomerase activity and the occurrence and development of oral squamous cell carcinoma. Methods TRAP-PCR-ELISA was used to detect and analyze telomerase activity in 32 specimens of oral squamous cell carcinoma, 15 adjacent tissues and 10 normal oral mucosa tissues. Results The telomerase activity in oral squamous cell carcinoma tissues was significantly higher than that in paracancerous tissues and normal tissues (P <0.05). The positive rate of telomerase in oral squamous cell carcinoma specimens was 71.87%, which was significantly higher than that in paracancerous tissues and normal tissues (P <0.01), and the pathological grade of squamous cell carcinoma with or without cervical lymph node metastasis Related. Conclusion The telomerase activity is closely related to the occurrence and development of oral squamous cell carcinoma