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目的:探讨新型鼻塞持续呼吸道正压通气(NCPAP)联合盐酸氨溴索治疗新生儿呼吸衰竭的临床效果。方法:新生儿呼吸衰竭患儿56例随机分为治疗组和对照组。治疗组用新型鼻塞NCPAP自主辅助通气模式联合大剂量盐酸氨溴索进行治疗,对照组以同步间隙指令通气+呼气末正压通气(SIMV+PEEP)模式辅助通气。观察辅助通气时间、住NICU时间、并发症发生率及住院费用指标。结果:治疗组辅助通气时间、住NICU时间、并发症发生率及住院费用方面均低于对照组,两组比较差异均有显著性,但两组病死率比较无统计学差异。结论:NCPAP联合盐酸氨溴索治疗新生儿呼吸衰竭,效果良好,早期使用可减少机械通气的时间。NCPAP联合盐酸氨溴索治疗新生儿呼吸衰竭,能缩短辅助通气时间、住NICU时间、降低并发症的发生率及减少住院费用。
Objective: To investigate the clinical effect of nasal continuous positive airway pressure (NCPAP) combined with ambroxol hydrochloride in neonatal respiratory failure. Methods: 56 neonates with respiratory failure were randomly divided into treatment group and control group. The patients in the treatment group were treated with new nasal obstruction nasal plug NCPAP and ambroxol hydrochloride bolus. The control group was assisted by SIMS + SIMP + PEEP. Observe the time of assisted ventilation, NICU time, the incidence of complications and hospitalization costs. Results: The time of assisted ventilation, the duration of NICU stay, the complication rate and the cost of hospitalization in the treatment group were lower than those in the control group. There was significant difference between the two groups, but there was no significant difference between the two groups. Conclusion: NCPAP combined with ambroxol hydrochloride in neonatal respiratory failure, the effect is good, early use can reduce the mechanical ventilation time. NCPAP combined with ambroxol hydrochloride in the treatment of neonatal respiratory failure can shorten the duration of assisted ventilation, NICU time, reduce the incidence of complications and reduce hospitalization costs.