论文部分内容阅读
用耗竭/补充/耗竭的设计,以克山病病区低硒粮饲料(含硒6μg/kg)喂养大鼠6周后,观察了补充紫阳高硒玉米(含硒7.241mg/kg)或亚硒酸钠硒(饲料含硒分别为221和223μg/kg)时以及停止补硒后,大鼠组织和血液硒水平以及谷胱甘肽过氧化物酶(GSH-px)活性的变化,评估了紫阳高硒玉米硒的相对生物利用率。结果表明:以血浆、肾、肝和心肌硒含量为指标时,高硒玉米硒的平均相对生物利用率(补硒2、4和6周时)与亚硒酸钠硒相似,分别为99、107、100和104%(亚硒酸钠定为100%);但以红细胞硒为指标时,高硒玉米硒的生物利用率(120%)高于亚硒酸钠硒;以心肌和红细胞 GSH-px 活性为指标时,其生物利用率(72和84%)低于亚硒酸钠硒。至再停止补硒3周时,高硒玉米维持组织硒水平和 GSH-px 活性的作用与亚硒酸钠相似。
The rats fed with low selenium diet (containing 6μg / kg of selenium) in Keshan disease ward for 6 weeks were treated with depletion / supplement / depletion design and the effects of supplementing Ziyang high-selenium corn (containing selenium 7.241mg / kg) Changes in selenium and selenium levels and glutathione peroxidase (GSH-px) activity in selenium sodium selenate (221 and 223 μg / kg selenium, respectively) and after selenium administration was discontinued Relative Bioavailability of Selenium in Ziyang High and Se Corn. The results showed that the average relative bioavailability of selenium in high selenium maize (selenium at 2, 4 and 6 weeks) was similar to that of selenium and selenite at the selenium content of plasma, kidney, liver and myocardium as 99, 107,100 and 104% (sodium selenite was set as 100%). However, the bioavailability of selenium (120%) was higher than that of selenium and selenium with red blood cell selenium as index. The myocardial and erythrocyte GSH -px activity as an indicator, its bioavailability (72 and 84%) is lower than that of sodium selenite. To stop selenium 3 weeks, high selenium corn tissue maintenance selenium levels and GSH-px activity similar to sodium selenite.