,Multiple Functions of Nuclear DNA Helicase Ⅱ (RNA helicase A) in Nucleic Acid Metabolism

• 作 者: Suisheng ZHANG Frank GROSSE
• 机 构: Department of Biochemistry,Institute of Molecular Biotechnology,Beutenbergstrasse 11,D-07745 Jena,Ge
• 出 处: 生物化学与生物物理学报（英文版）
• 发表日期: 2004年3期
• 关键词: DNA and RNA helicase maleless (MLE) X-chromosome dosage compensation dsRBD RGG-b

Nuclear DNA helicase Ⅱ(NDH Ⅱ),or RNA helicase A(RHA),was initially discovered in mammals by conventional protein purification methods.Molecular cloning identified apparent sequence homologies between NDH Ⅱ and a Drosophila protein named maleless(MLE),the latter being essential for the Drosophila X-chromosome dosage compensation.Increasing amounts of evidence suggest that NDH Ⅱ is involved in multiple aspects of cellular and viral DNA and RNA metabolism.Moreover the functions of NDH Ⅱ may have potential clinical implications related to viral infection,autoimmune diseases,or even tumorigenesis.