论文部分内容阅读
目的评价平阳霉素碘化油乳剂(pingyangmycin oleum iodisatum emulsion,PLE)的药物效价;分析缝扎注射PLE治疗口腔颌面部静脉畸形的临床疗效和不良反应。方法采用碘化油与平阳霉素(pingyangmycin,PYM)混合后碘含量测定,评价PYM的药物效价;通过X线透视观察缝扎注射后病变内碘化油滞留情况;记录、分析治疗病例的临床疗效及不良反应。结果 PYM与碘化油混合后碘含量不变;X透视显示,4h内病变碘化油浓度无明显改变,4~30h逐渐排空;40例患者经缝扎注射PLE均治愈,随访12~24个月无复发;全部病例均未出现肺纤维化、脑栓塞、肺栓塞、呼吸困难、组织坏死及功能障碍等症状。结论 PYM与碘化油混合后药物效价不受影响;缝扎注射PLE治疗口腔颌面部静脉畸形,可有效增加治疗药物对静脉畸形的直接作用时间和浓度,显著提高临床治疗效果,减少不良反应。
Objective To evaluate the drug titer of pingyangmycin oleum iodineatum emulsion (PLE). To analyze the clinical efficacy and adverse reactions of suture injection of PLE for oral venous malformations of oral and maxillofacial region. Methods The iodine content of iodized oil and pingyangmycin (PYM) were measured to evaluate the drug titer of PYM. The retention of iodized oil in the lesion after suture injection was observed by X-ray. The records of the treated cases Clinical efficacy and adverse reactions. Results PYM and iodized oil mixed iodine content unchanged; X fluoroscopy showed that within 4h lesions iodized oil concentration no significant change 4 ~ 30h gradually emptying; 40 patients were sutured PLE were cured, followed up for 12 to 24 No recurrence occurred in all the cases. No pulmonary fibrosis, cerebral embolism, pulmonary embolism, dyspnea, tissue necrosis and dysfunction were observed in all cases. Conclusions The drug titer of PYM mixed with iodized oil is unaffected. Suture injection of PLE in treatment of oral and maxillofacial venous malformations can effectively increase the time and concentration of therapeutic drugs on venous malformation, significantly improve the clinical effect and reduce the adverse effects reaction.