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目的探讨美托洛尔联合心脑宁胶囊在治疗室早方面的有效性、安全性分析。方法选取2012年6月-2014年6月心血管内科收治的室性早搏确诊患者90例。所有患者随机分为联合组、美托洛尔组和心脑宁组各30例。联合组予心脑宁胶囊+美托洛尔治疗;美托洛尔组仅予美托洛尔治疗;心脑宁组仅予心脑宁治疗。3组均连续服用28d。比较3组临床效果、心电图改善及不良反应。结果联合组总有效率93.0%明显优于美托洛尔组的76.0%及心脑宁组的67.0%,差异有统计学意义(P<0.05);美托洛尔组与心脑宁组临床疗效比较差异无统计学意义(P>0.05)。联合组心电图、24h室性早搏平均次数改善情况明显优于美托洛尔组及心脑宁组。3组治疗期间均无严重不良反应发生。结论心脑宁胶囊合并美托洛尔治疗室性早搏临床有效率高,安全性好。值得临床推广应用。
Objective To investigate the efficacy and safety of metoprolol combined with Xinnaoning Capsule in the treatment of early asphyxia. Methods Totally 90 patients with ventricular premature beats admitted from June 2012 to June 2014 in our department of cardiovascular medicine were selected. All patients were randomly divided into combined group, metoprolol group and Xinnaoning group of 30 cases. Combination group to Xinnaoning capsule + metoprolol treatment; metoprolol group metoprolol treatment; Xinnao Ning group only to the brain and brain Ning treatment. 3 groups were taking 28d continuously. The clinical effects, ECG improvement and adverse reactions in the three groups were compared. Results The total effective rate in combination group was 93.0%, which was significantly better than 76.0% in metoprolol group and 67.0% in Xinnaoning group, the difference was statistically significant (P <0.05). Metoprolol group and Xinnaoning group The difference was not statistically significant (P> 0.05). Combined group electrocardiogram, 24-h ventricular premature beats average improvement was significantly better than the metoprolol group and Xinnao Ning group. No serious adverse reactions occurred in the three groups during the treatment. Conclusions Xinnaoning capsule combined with metoprolol in the treatment of ventricular premature beats clinical effective, good safety. Worthy of clinical application.