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硝酸盐对机体没有直接的危害,当它变成亚硝酸盐时,则会带来危害。除引起血红蛋白变化、血管舒张、肝脏维生素A贮存功能降低等毒作用外,它还是亚硝基化合物的重要前体。许多作者证明了在适宜的环境下,在体内、外均可由前体形成亚硝基化合物。然而,至今对硝酸盐在体内的生物转化却注意不够,但它确是有害作用的先决条件。本文就10名成人的硝酸盐摄入量的日平均值以及62名5～22周龄的婴儿和成人体内的硝酸盐转归及可能影响体内硝酸盐生物转化的因素做了初步研究。方法:根据10年来食物中硝酸盐、亚硝酸
Nitrate is not directly harmful to the body, when it becomes nitrite, it will bring harm. In addition to causing changes in hemoglobin, vasodilation, liver vitamin A storage function and other toxic effects, it is an important precursor of nitroso compounds. Many authors have demonstrated that nitroso compounds can be formed from precursors both in vitro and in vivo under suitable conditions. However, to date, there has been insufficient attention to the biotransformation of nitrates in the body, but it is indeed a prerequisite for harmful effects. In this paper, the daily average nitrate intake of 10 adults and the nitrate turnover in 62 infants and adults aged 5-22 weeks and the factors that may affect the nitrate conversion in vivo were preliminarily studied. Methods: According to 10 years of food nitrate, nitrite