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一、中毒途径主要经皮肤、消化道和呼吸道吸收中毒。误服,自服或食用染有毒物的水和食物,易从胃内吸收。皮肤的真皮层毛细血管和淋巴管比较丰富,杀虫脒盐酸盐水溶液可穿过表皮达真皮进入血液循环。正常人的肺泡面积较大,肺内毛细血管丰富,药物被经肺吸收后,亦可迅速进入血液循环。药物在体内分布的浓度依次为肝、肾、肺、脾、脑、胰和脂肪。药物代谢迅速,以杀虫脒原型及代谢产物形式从泌尿道和消化道排出,组织内无明显蓄积。二、中毒机理杀虫脒的中毒机理目前尚未完全阐明,主要表现在以下几个方面。(一)抑制单胺氧化酶:体外试验证明,
First, the main route of poisoning by the skin, gastrointestinal and respiratory absorption poisoning. Misuse, self-service or consumption of toxic water and food, easily absorbed from the stomach. The dermis of the skin is rich in capillaries and lymphatic vessels, and chlordimeform hydrochloride hydrochloride solution can reach the blood circulation through the dermis up to the dermis. Alveolar area of normal large pulmonary capillary rich in drugs absorbed by the lungs, but also can quickly enter the blood circulation. The distribution of drugs in the body in order of concentration of liver, kidney, lung, spleen, brain, pancreas and fat. Rapid drug metabolism to chlordimeform prototype and metabolites from the urinary tract and digestive tract discharge, no significant accumulation of tissue. Second, the poisoning mechanism Chlordimeform poisoning mechanism has not been fully elucidated, mainly in the following areas. (A) inhibition of monoamine oxidase: in vitro tests show that,