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目的:研究卵巢低反应(POR)患者采用拮抗剂方案加用生长激素(GH)对子宫内膜容受性及妊娠结局的影响。方法:对采用拮抗剂方案促排卵行体外受精-胚胎移植(IVF-ET)助孕的188例POR患者的资料进行回顾性分析。以加用GH者为研究组(n=98),其余不加用GH者为对照组(n=90),比较组间的临床资料、实验室数据及妊娠结局,以评估GH治疗对POR患者的临床疗效。结果:研究组的Gn使用时间、Gn RH-A使用时间及总Gn使用量显著少于对照组,而获卵数、MII卵子数、受精卵数、优质胚胎数、h CG注射日血E2水平均显著高于对照组,差异均有统计学意义(P<0.05);h CG注射日子宫内膜厚度组间比较差异无统计学意义(P>0.05),但研究组子宫内膜血流改善显著,差异有统计学意义(P<0.05);研究组生化妊娠率、临床妊娠率、种植率、活产率略高于对照组,但差异无统计学意义(P>0.05)。结论:对于POR患者,GH改善了子宫内膜血流,可能提高了子宫内膜容受性,但对妊娠结局没有改善。
OBJECTIVE: To study the effect of antagonist regimen plus growth hormone (GH) on endometrial receptivity and pregnancy outcomes in patients with low ovarian response (POR). Methods: The data of 188 POR patients with IVF-ET assisted by ovulation induction therapy were retrospectively analyzed. GH was used as the study group (n = 98), and the rest without GH as the control group (n = 90). Clinical data, laboratory data and pregnancy outcomes were compared between groups to evaluate the effect of GH treatment on POR patients The clinical efficacy. Results: The Gn usage time, Gn RH-A usage time and total Gn usage in the study group were significantly less than those in the control group. The number of oocytes, the number of MII eggs, the number of fertilized eggs, the number of high quality embryos, the blood E2 level on h CG injection day (P <0.05). There was no significant difference in endometrial thickness between h CG injection on the day of CG injection (P> 0.05), but the endometrial blood flow in the study group was improved (P <0.05). The biochemical pregnancy rate, clinical pregnancy rate, implantation rate and live birth rate in the study group were slightly higher than those in the control group, but the difference was not statistically significant (P> 0.05). CONCLUSIONS: GH improves endometrial blood flow in POR patients and may improve endometrial receptivity with no improvement in pregnancy outcomes.