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胃癌是威胁人类最常见的恶性肿瘤之一,目前的治疗方法主要是手术和化疗.但对中晚期胃癌的疗效却欠理想.国际上80年代兴起的生物疗法,尤其是基因治疗,为恶性肿瘤的治疗翻开了崭新的一页.“自杀基因”即为目前研究较多的基因.其中CD基因是研究最多的自杀基因之一,它能将对哺乳动物细胞无毒性的药物(称为前药)转化为有毒性的药物,从而导致转基因细胞的死亡.CD基因的前药为5-氟胞嘧啶(5-Fc),它被CD转化为5-Fu导致转基因细胞的死亡.但它抗肿瘤更重要的作用是产生“旁观者效应”,就是不仅转基因细胞被杀死,而且其周围大量未转基因的细胞亦被杀死.Huber等认为CD基因的旁观者效应是前药转化的
Gastric cancer is one of the most common malignant tumors that threaten humans. The current treatment methods are mainly surgery and chemotherapy. However, the efficacy of advanced gastric cancer is unsatisfactory. The international rise of biological therapy in the 80s, especially gene therapy, is a malignant tumor. The treatment has opened a new page. “Suicide gene” is the most studied gene. Among them, the CD gene is one of the most studied suicide genes. It can treat drugs that are non-toxic to mammalian cells (known as the former (drug) is converted to a toxic drug, leading to the death of the transgenic cell. The prodrug of the CD gene is 5-fluorocytosine (5-Fc), which is converted to 5-Fu by CD to cause the death of the transgenic cell. But it is resistant to The more important role of the tumor is to produce a “bystander effect” in which not only the transgenic cells are killed, but also a large number of untranslated cells around them are killed. Huber et al believe that the bystander effect of the CD gene is the conversion of prodrugs.