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胺碘酮(Amiodarone)是目前应用较广的抗心律失常药,对心脏的作用特征类似甲低时的心脏表现。该药属苯并呋喃衍生物,其化学结构与甲状腺激素相似。每分子药物含两个碘原子,碘占分子量的37.2%。200毫克(口服片剂一片)药物含碘约75毫克。因此,该药与甲状腺的关系应引起心脏和内分泌工作者的重视。一、胺碘酮对血清甲状腺激素的影响 1975年Pritchard就发现,服用胺碘酮的病人血清T_4显著升高、T_3轻度降低。伴随T4升高心率反而减慢。后来Burger等的研究不仅发现T_3、T_4有相同变化,而且T4的另一外周代谢产物——反T_3(re-
Amiodarone is the most widely used anti-arrhythmic drug and its effect on the heart is similar to that of hypothyroidism. The drug is benzofuran derivative, its chemical structure and thyroid hormone similar. Each molecule of medicine contains two iodine atoms, accounting for 37.2% of the molecular weight. 200 mg (oral tablets) drugs containing iodine about 75 mg. Therefore, the relationship between the drug and the thyroid should cause heart and endocrine workers attention. First, the impact of amiodarone on serum thyroid hormone 1975 Pritchard found that patients taking amiodarone serum T_4 significantly increased, T_3 slightly lower. With T4 increased heart rate but slowed down. Later Burger and other studies not only found that T_3, T_4 have the same changes, and T4 another peripheral metabolite - the reverse T_3 (re-