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目的观察厄贝沙坦治疗老年人轻、中度原发性高血压的降压疗效及对左室舒张功能的影响。方法采用自身对照开放试验,选取34例老年人轻、中度原发性高血压患者,每天晨起顿服厄贝沙坦150mg/d,疗程12W。每2W随访一次,观察血压变化及不良反应和治疗前后超声心动图各项指标变化。结果经过12W治疗后,厄贝沙坦降压总有效率为88.23%,血压较治疗前有明显下降(P<0.01)。超声心动图检测二尖瓣舒张早期血流速度E峰值较前升高,二尖瓣舒张晚期血流速度A峰值较前降低,E/A比值提高,与治疗前相比均有显著性差异(P均<0.05)。结论厄贝沙坦时于老年人轻、中度原发性高血压降压疗效确切,而且可明显改善左心室舒张功能,不良反应轻微。
Objective To observe the antihypertensive effect of irbesartan in the treatment of mild to moderate essential hypertension in elderly patients and its effect on left ventricular diastolic function. Methods Self-control open trial, 34 elderly patients with mild to moderate essential hypertension, irbesartan Dayton daily dose of 150mg / d, treatment 12W. Followed up every 2W, observed changes in blood pressure and adverse reactions and echocardiography before and after treatment of various indicators. Results After 12W treatment, the total effective rate of irbesartan was 88.23%, and the blood pressure was significantly lower than that before treatment (P <0.01). Echocardiography was used to detect mitral early diastolic blood flow velocity E peak was higher than before, mitral valve diastolic blood flow velocity peak A earlier than before, E / A ratio increased, compared with before treatment were significantly different ( P <0.05). Conclusion Irbesartan in the elderly mild to moderate essential hypertension antihypertensive effect, and can significantly improve left ventricular diastolic function, minor adverse reactions.