Osthole improves synaptic plasticity in the hippocampus and cognitive function of Alzheimer＇s diseas

• 作 者: Xiaohua Dong Li Zhang Wei Li X
• 机 构: DepartmentofPharmacology,DepartmentofPharmacology,DepartmentofOrthopedics
• 出 处: 中国神经再生研究：英文版
• 发表日期: 2012年30期
• 关键词: 阿尔茨海默氏病 海马神经元 大鼠模型 蛇床子素 突触可塑性 谷氨酸 认知功能 γ-氨基丁酸 osthole Alzheimer＇s disease learni
• 基金项目: the Natural Science Foundation of Hebei Province，Key Project of Hebei Province Health Department

Osthole, an effective monomer in Chinese medicinal herbs, can cross the blood-brain barrier and protect against brain injury, with few toxic effects. In this study, a rat model of Alzheimer's disease was established after intracerebroventricular injec