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目的 :观察基因重组牛碱性成纤维细胞生长因子 (rbFGF)对急性创面和慢性创面愈合的促进作用。方法 :治疗组 (12 82例 )和对照组 (439例 )被分为深Ⅱ度烧伤、浅Ⅱ度烧伤、供皮区 (包括刃厚和中厚供皮区 )和慢性 (包括残余小创面和慢性溃疡 )创面 4大类。分别观察应用rbFGF后不同时间创面愈合面积的百分比、创面完全愈合时间 ,以及用药前后的全身情况和不良反应。结果 :浅Ⅱ度烧伤 8d愈合率和创面完全愈合时间 ,对照组为 5 1 7%± 2 6 4 %和 (12 6± 2 9)d(P <0 0 0 1) ,治疗组为 70 6 %± 2 5 0 %和 (10 5± 2 4 )d(P <0 0 0 1)。深Ⅱ度烧伤 15d愈合率和创面完全愈合时间 ,对照组为 5 3 3%± 2 5 4 %和 (2 1 9± 5 5 )d(P <0 0 0 1) ,治疗组为 6 9 7%± 2 7 0 %和 (18 5± 4 4 )d(P <0 0 0 1)。供皮区创面 8d愈合率和创面完全愈合时间 ,对照组为 5 7 6 %± 2 9 4 %和(11 4± 2 7)d(P <0 0 0 1) ,治疗组为 72 1%± 2 8 0 %和 (9 5± 2 4 )d(P <0 0 0 1)。慢性创面完全愈合时间 ,对照组为 (2 8 0± 18 0 )d ,治疗组 (2 2 1± 16 )d(P =0 0 6 8)。用药前后血常规、肝、肾功能无异常变化。结论 :基因重组牛碱性成纤维细胞生长因子能够显著地促进创面
Objective: To observe the effect of rbFGF on the healing of acute and chronic wounds. Methods: The treatment group (1282 cases) and the control group (439 cases) were divided into deep second degree burn, superficial second degree burn, donor area (including blade thickness and medium donor area) and chronic (including residual small wound And chronic ulcers) Wound 4 categories. The percentage of wound healing area at different times after wound healing was observed, the wound healing time, and the systemic and adverse reactions before and after treatment were observed. Results: The healing rate of wounds at 8th degree and the complete wound healing time were 51.7% ± 246% and 12 6 ± 29 days (P <0.01) in the control group and 706 in the treatment group % ± 250% and (105 ± 2 4) d (P <0.001). The healing rate of deep second degree burn for 15 days and wound healing time were 53.3% ± 2.54% and 291.5 ± 5% (P <0.01) in control group and 697 % ± 270% and (18 ± 4 ± 4) days (P <0 0 0 1). In the control group, the healing rate of the wounds on the 8th day and the complete wound healing time were 57.6% ± 294% and 114 ± 27 days respectively (P <0.01), and the treatment group was 72.1% ± 28 0% and (95 ± 2 4) d (P <0 0 0 1), respectively. The complete healing time of chronic wounds was (2800 ± 1860) days in the control group and (2121 ± 16) days in the treatment group (P = 0.086). Before and after treatment of blood, liver, kidney function without abnormal changes. Conclusion: Recombinant bovine basic fibroblast growth factor can significantly promote wounds