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近年研究结果显示肾间质病变与慢性肾功能衰竭进展密切相关。［１］。肾间质纤维化以间质成纤维细胞的大量增殖和细胞外基质的过度沉积为特征。多种细胞因子具有致纤维化的作用，但转化生长因子－β（ｔｒａｎｓｆｏｒｍｉｎｇ ｇｒｏｗｔｈ ｆａｃｔｏｒβ，ＴＧＦ－β）可
Recent studies have shown that interstitial lesions are closely related to the progress of chronic renal failure. [1]. Renal interstitial fibrosis is characterized by massive proliferation of interstitial fibroblasts and excessive deposition of extracellular matrix. A variety of cytokines have a role in fibrosis, but transforming growth factor-β (TGF-β)