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心房利钠肽(ANP)是从哺乳类动物心房肌细胞中分离出来的,已发现对肾脏血液动力学、电解质排泄、平滑肌、血压、血循环以及肾素-血管紧张素-醛固酮系统均具有重要生理影响。本研究是在24例慢性肝病患者中用放免法测定ANP的水平,检查其对肾素-血管紧张素-醛固酮系统和肝功能试验的关系。24例中3例组织学证实酒精性肝纤维变性,4例慢性活动性肝炎,13例肝硬化(其中2例有腹水),4例肝细胞癌(其中1例有腹水)。上述患者均有肝硬化史。另确定34名健康志愿者(男女各半)血浆中ANP的范围作为正常对照。
Atrial natriuretic peptide (ANP), isolated from mammalian atrial myocytes, has been found to have important physiological properties in renal hemodynamics, electrolyte excretion, smooth muscle, blood pressure, blood circulation, and renin-angiotensin-aldosterone systems influences. In this study, the level of ANP was determined by radioimmunoassay in 24 patients with chronic liver disease and its relationship with renin-angiotensin-aldosterone system and liver function test was examined. Three of 24 patients were histologically confirmed alcoholic liver fibrosis, 4 chronic active hepatitis, 13 cirrhosis (2 ascites) and 4 hepatocellular carcinoma (1 ascites). All patients had a history of cirrhosis. Another 34 healthy volunteers (half male and female) to determine the range of plasma ANP as a normal control.