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目的对比观察保定市传染病医院常用两组治疗小儿手足口病方案的临床疗效。方法将60例初诊为普通型手足口病患儿随机分为两组,每组30例,一组给予更昔洛韦联合痰热清注射液治疗(治疗1组),一组给予更昔洛韦联合西咪替丁(治疗2组),对比两组患儿的临床疗效及不良反应的发生率。结果治疗1组热退、疱疹消退以及口腔溃疡愈合时间均明显短于治疗2组(P<0.05);治疗1组的显效率为83.3%,总有效率为93.3%,明显高于治疗2组的73.3%和83.3%,两组比较差异有统计学意义(P<0.05);两组治疗过程中均无严重不良反应发生。结论更昔洛韦联合痰热清注射液治疗小儿手足口病的临床疗效优于更昔洛韦联合西咪替丁,不良反应小,值得在临床中推广应用。
Objective To compare the clinical efficacy of two groups commonly used in the treatment of hand-foot-mouth disease in children in the infectious disease hospital of Baoding city. Methods Sixty cases of newly diagnosed common hand, foot and mouth disease were randomly divided into two groups (n = 30 in each group). One group received ganciclovir combined with Tanreqing Injection (group 1) and one group received ganciclovir Wei combined with cimetidine (treatment group 2), compared the clinical efficacy and incidence of adverse reactions in both groups. Results The heat withdrawal, the regression of herpes and the healing time of oral ulcer in treatment group 1 were significantly shorter than those in treatment group 2 (P <0.05). The effective rate was 83.3% and the total effective rate was 93.3% in treatment group 1, which was significantly higher than that in treatment 2 (73.3%) and 83.3% (83.3%), respectively. The difference between the two groups was statistically significant (P <0.05). No serious adverse reactions occurred in the two groups during the course of treatment. Conclusions Ganciclovir combined with Tanreqing Injection is superior to Ganciclovir combined with cimetidine in the treatment of hand-foot-mouth disease in children. The adverse reactions are small and worthy of promotion and application in clinical practice.